Emerging Therapies for Childhood Polycystic Kidney Disease

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Emerging Therapies for Childhood Polycystic Kidney Disease

Cystic kidney diseases comprise a varied collection of hereditary disorders, where renal cysts comprise a major element of their pleiotropic phenotype. In pediatric patients, the term polycystic kidney disease (PKD) commonly refers to two specific hereditary diseases, autosomal recessive polycystic kidney disease (ARPKD) and autosomal dominant polycystic kidney disease (ADPKD). Remarkable progr...

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Polycystic kidney disease.

A number of inherited disorders result in renal cyst development. The most common form, autosomal dominant polycystic kidney disease (ADPKD), is a disorder most often diagnosed in adults and caused by mutation in PKD1 or PKD2. The PKD1 protein, polycystin-1, is a large receptor-like protein, whereas polycystin-2 is a transient receptor potential channel. The polycystin complex localizes to prim...

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ژورنال

عنوان ژورنال: Frontiers in Pediatrics

سال: 2017

ISSN: 2296-2360

DOI: 10.3389/fped.2017.00077